1. Chances are pretty good (that)... 很有可能......，后面表述原因

例句：

Alone on Instagram? Chances are pretty good your pictures suck.

你的Instagram没人气？很可能是因为你的照片太挫了。

Got no boyfriend? Chances are pretty good you're ugly.

木有男友？很可能因为你太丑了。

2. a kick in the teeth 极度的失望，沉重的打击，重大的挫折

例句：

The Government's decision is a real kick in the teeth for the unions.

政府的决定是对工会的沉重打击.

Not being accepted by colleges is surely a kick in the teeth for an excellent student like Kate.

对像凯特这样优秀的学生来说，没被大学录取肯定是一个重大打击。