“一窍不通”，意思是指没有一窍是贯通的，比喻一点儿也不懂（be utterly ignorant of）。可以翻译为“it's all Greek to somebody”，“all Greek to me”是英文惯用语，比喻“something is not understandable”。

例句：

你弄懂这些说明了吗？我根本一窍不通！

Can you make sense of these instructions? It's all Greek to me!

对不起，我不知道你说的是什么，我对那一窍不通。

Sorry, I don't understand what you said. It is Greek to me.