Set in the late 19th  century monster hunter Dr. Gabriel Van Helsing(Jackman)　is summoned to  a mysterious land in East Europe to vanquish evil forces……evil forces with names like Count Dracula (Roxburgh),the  Wolf Man(Kemp),and Franken-stein's Monster(Hensley).Assisting him once he gets there is Anna(Beekinasle),the heir of a long-running family committed to hunting down and destroying Dracula.

故事发生在１９世纪末，罗马尼亚神秘古镇特兰西瓦尼亚出现了许多可怕的怪物，他们在城市里肆虐，不断地有人丧生在魔爪下。为了剿灭特兰西瓦尼亚的邪恶势力，天主教廷远赴美国邀请怪物猎人范海辛博士，替他们对付吸血鬼、科学怪人和狼人……

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